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The effectiveness of these administration strategies depends on various factors, including bioavailability, drug formulation, gastrointestinal conditions, and systemic distribution, which, if not optimized, could compromise therapeutic outcomes and limit the antibiotics efficacy against targeted infections (McCarthy and Avent, 2020
230(32.67%) patients defaulted in follow-up at a mean of 2.4 1.2 years
Glutamateglutamine cycling Biochemical pathway that describes the uptake and conversion of glutamate to glutamine by astrocytes and the subsequent transfer of glutamine back to neurons for conversion to glutamate
Good candidates tend to be patients with less severe symptoms, or those in whom more invasive options pose an increase risk
In addition, outcome measurements were also variable, as some studies measured symptoms of a mental illness, whilst others required a diagnosis
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